Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 46, Pages 12547-12549Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15716g
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Funding
- Association Francaise contre les Myopathies (AFM)
- Vaincre la Mucoviscidose (VLM)
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A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.
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