Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 29, Pages 8358-8360Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12413g
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Funding
- NSFC [21025522, 20975051, 20890021]
- NSFC for Creative Research Groups [20821063]
- 973 Program of China [2007CB936404]
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We report here an ultrasensitive DNA detection approach which combines Au NPs enhanced electrochemiluminescence (ECL) of the CdS nanocrystal (NC) film with isothermal circular amplification reaction of polymerase and nicking endonuclease (NEase). By the double-signal amplification, this approach could sensitively respond down to 5 aM DNA.
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