Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 39, Pages 10966-10968Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13705k
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- Q.U.B.
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DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.
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