4.7 Article

Reaction of arynes with amino acid esters

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 20, Pages 5822-5824

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11234a

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An efficient route to a variety of 2-phenylindolin-3-ones from amino acid methyl esters has been developed. The reaction of amino acid methyl esters with benzyne prepared from 2-(trimethylsilyl) phenyl triflate and CsF gave 2-phenylindolin-3-ones in moderate to good yields.

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