Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 41, Pages 11483-11485Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14292e
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Funding
- Servier Company
- Universite Paris-Sud
- CNRS
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The first example of the enantioselective methyl C-H activation by an intramolecular ArPdX species and subsequent cyclisation was developed. Palladium catalysts using commercially available chiral diphosphines yield good ee's (up to 93% ee) in the synthesis of 2-methyl indolines from 2-halo N-isopropyl anilides. This approach was also employed for the synthesis of enantioenriched cyclohexyl fused indolines with moderate enantioselectivities.
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