4.7 Article

Bacteria-based AND logic gate: a decision-making and self-powered biosensor

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 11, Pages 3060-3062

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05037g

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Funding

  1. NSF [0939882]
  2. Chinese Scholarship Council

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We developed a bacteria-based AND logic gate using a Pseudomonas aeruginosa lasI/rhlI double mutant with two quorum-sensing signaling molecules as the input signals. We showed a distinct electrical output signal, despite the complexity and continuous regulation of metabolic reactions of living cells.

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