4.7 Article

A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 17, Pages 5043-5045

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10641d

Keywords

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Funding

  1. CSIC [200880I221]
  2. FCT (MCTES) (Portugal) [PTDC/SAUNEU/64151/2006]
  3. ISCIII (MCINN, Spain)
  4. MICINN [SAF2006-08764-C02-01, SAF2009-07271, CTQ2009-10478]
  5. Comunidad de Madrid [S/SAL-0275-2006]

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The Sandmeyer reaction of differently C-2 substituted N-(prop-2yn-1-ylamino)pyridines is an efficient, mild, new and practical method for the stereospecific synthesis of (E)-exo-halomethylene bicyclic pyridones bearing the imidazo[1,2-a]pyridine heterocyclic ring system.

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