4.7 Article

Chiral phosphine-squaramides as enantioselective catalysts for the intramolecular Morita-Baylis-Hillman reaction

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 3, Pages 1012-1014

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03187a

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Funding

  1. National Natural Science Foundation of China [20772029]
  2. Program for New Century Excellent Talents in University [NCET-07-0286]
  3. Fundamental Research Funds for the Central Universities

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Novel squaramides containing tertiary phosphine were developed as chiral bifunctional organic catalysts to promote the asymmetric intramolecular Morita-Baylis-Hillman reaction of omega-formyl-enones. The adducts were obtained in high yields with good-to-excellent enantioselectivity (up to 93% ee).

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