Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 48, Pages 12754-12761Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14042f
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Funding
- National Research Foundation of Korea (NRF)
- WCU
- NRF
- Korean Ministry of Education, Science and Technology (MEST)
- BK21 Program
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We demonstrated the importance of maximized skeletal diversity of privileged substructures for the construction of a drug-like small-molecule library through a series of high-throughput screening and subsequent bioevaluations. Our divergent pDOS strategy can provide an efficient approach for the discovery of novel small-molecule modulators with excellent specificity.
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