Journal
PSYCHOLOGY & HEALTH
Volume 15, Issue 6, Pages 881-891Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08870440008405589
Keywords
psychological stress; academic stress; DNA repair; DNA damage; nucleotide excision repair
Funding
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NCI NIH HHS [P30 CA047904] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA047904] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000005] Funding Source: NIH RePORTER
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Research has shown that lymphocytes of high-distress patients have reduced DNA repair relative to that of low-distress patients and healthy controls. Furthermore, deficits in repair are associated with an increased risk of cancer. Using and academic stress model, we hypothesized that students would exhibit lower levels of Nucleotide Excision Repair (NER) during a stressful exam period when compared to a lower stress period. Participants were 19 healthy graduate level students. NER was measured in lymphocytes using the unscheduled DNA synthesis (UDS) assay with slide autoradiography. Contrary to prediction, mean values for NER significantly increased during the higher stress period relative to the lower stress period controlling for background differences in repair. Furthermore, lymphocytes had significantly increased repair of endogenous damage during the higher stress period. Stress appears to directly increase DNA repair. Additionally, stress may increase DNA repair indirectly by increasing damage to DNA.
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