4.7 Article

Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 47, Pages 12640-12642

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15061h

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Funding

  1. Fundamental R&D Program for Core Technology of Materials
  2. Ministry of Knowledge Economy, Republic of Korea
  3. Korea Research Foundation (KRF)
  4. Korean government (MEST) [2010-0011160]

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We have presented a fluorescent probe 1 that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it is readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activity in buffered aqueous solution, and further utilized for the visualization of endogenous tyrosinase activity in living melanoma cells.

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