4.7 Article

Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg2+ detection

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 28, Pages 8010-8012

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12384j

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Funding

  1. National Natural Science Foundation of China [20874077]
  2. University of Ministry of Education
  3. Fundamental Research Funds for the Central Universities of China

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Controllable turn off/on fluorescent sensors for Hg2+ detection were developed by designing different label-free DNA sequences and using the minor groove dye of DAPI. These assays exhibit high sensitivity and selectivity, with the detection limits of 5 nM and 1.5 nM for turn off and turn on sensors, respectively.

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