4.3 Article Proceedings Paper

Impulsivity

Journal

JOURNAL OF PSYCHOPHARMACOLOGY
Volume 14, Issue 2, Pages S39-S44

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1177/02698811000142S106

Keywords

borderline personality disorder; impulsivity; paraphilias; pathological gambling; sertraline; sexual addictions; SSRIs

Funding

  1. NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000071] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE ON DRUG ABUSE [R01DA010234] Funding Source: NIH RePORTER
  3. NCRR NIH HHS [5 M01-RR00071] Funding Source: Medline
  4. NIDA NIH HHS [IR01DA10234-01A2] Funding Source: Medline

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Disorders characterized by impulsivity include disorders of impulse control (intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania), paraphilias, sexual impulsions and sexual addictions and impulsive aggression personality disorders (borderline, antisocial, histrionic and narcissistic personality disorders). Impulsivity has a substantial impact on both individuals and society. Impulse control, disorders may be conceptualized as a subset of the obsessive-compulsive spectrum. In this article, we examine the genetic and neurobiological aetiology of these disorders and possible treatment options. The link between serotonergic dysfunction and the pathophysiology of impulsivity is discussed, and studies that examine the efficacy of various selective serotonin reuptake inhibitors and other alternatives in the treatment of impulsive disorders such as pathological gambling, sexual addictions and borderline personality disorder are presented.

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