4.7 Article

Combination of pi-pi stacking and electrostatic repulsion between carboxylic carbon nanoparticles and fluorescent oligonucleotides for rapid and sensitive detection of thrombin

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 40, Pages 11321-11323

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14445f

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Funding

  1. National Natural Science Foundation of China [21075032, 21005026, 21135001]
  2. 973 National Key Basic Research Program [2011CB911000]
  3. Hunan Province Key Project of Scientific & Technical Programs [2010TP4013-1]

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On the basis of simultaneous electrostatic repulsion and pi-pi stacking interactions of carboxylic carbon nanoparticles (cCNPs) with single-stranded DNA, a noncovalent assembly of cCNPs and fluorescent aptamers is reported for rapid, sensitive, and selective detection of thrombin.

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