Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 29, Pages 8367-8369Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11780g
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- National Institute of Biomedical Innovation (NIBIO)
- JSPS
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Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
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