Journal
BREAST CANCER RESEARCH
Volume 2, Issue 6, Pages 417-422Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/bcr88
Keywords
breast cancer; interconverted phenotype; thrombin receptor; TIE2
Categories
Funding
- NCI NIH HHS [R01 CA059702, R37 CA059702, CA59702, CA83137] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R21CA083137, R37CA059702, R01CA059702] Funding Source: NIH RePORTER
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During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. The molecular profile of these aggressive tumor cells suggests that they have a deregulated genotype, capable of expressing vascular phenotypes. Similarly, the embryonic-like phenotype expressed by the aggressive human breast cancer cells is associated with their ability to express a variety of vascular markers. These studies may offer new insights for consideration in breast cancer diagnosis and therapeutic intervention strategies.
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