4.7 Article

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 23, Pages 6629-6631

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11205h

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Funding

  1. EPSRC
  2. Advantage West Midlands
  3. University of Birmingham
  4. Peter Ashton
  5. Graham Burns (HPLC)
  6. EPSRC [EP/G007578/1] Funding Source: UKRI
  7. Engineering and Physical Sciences Research Council [EP/G007578/1] Funding Source: researchfish

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A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

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