Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 33, Pages 9459-9461Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12740c
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Funding
- National Natural Science Foundation of China [21001043, 51072053]
- Natural Science Foundation of Shanghai [10ZR1407500]
- Fundamental Research Funds for the Central Universities [WD0911012, WK1013001]
- New Century Excellent Talents in University [NCET-10-0379]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0825]
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A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.
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