4.7 Article

Indium mediated allylation in peptide and protein functionalization

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 32, Pages 9066-9068

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12926k

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Funding

  1. Nanyang Technological University
  2. Singapore Ministry of Education [T2-2-067]
  3. Novartis Institute for Tropical Diseases

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Indium-mediated allylation has been used in the site-selective functionalization of N-terminal aldehydes of peptides and proteins. This is the first demonstration of indium-mediated C-C bond formation in protein labelling studies under mild and environmentally friendly conditions.

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