4.7 Article

Nitroolefin-based coumarin as a colorimetric and fluorescent dual probe for biothiols

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 39, Pages 11029-11031

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14299b

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Funding

  1. Natural Science Foundation of China (NSFC) [20772073, 21072121]

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A coumarin-based thiol probe featuring the 1,4-addition reaction of thiols to nitroolefin was reported. The molecular probe exhibited higher selectivity toward biothiols (Cys, Hcy and GSH) than other amino acids.

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