4.7 Article

Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 16, Pages 4784-4786

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05616b

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Funding

  1. National Natural Science Foundation of China [20772084, 21021001]
  2. National Basic Research Program of China [2010CB833300]

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The first Lewis base-catalysed chemoselective asymmetric N-allylic alkylation of enamides with Morita-Baylis-Hillman carbonates has been developed, which affords multifunctional products in moderate to high enantioselectivity (up to 92% ee).

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