Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 17, Pages 4971-4973Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc00020a
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Funding
- Hong Kong Polytechnic University
- NSFC-RGC [N_PolyU 508/06]
- University Grants Committee [AoE/P-10/01, SEG_PolyU01]
- Research Committee of the Hong Kong Polytechnic University
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A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.
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