4.7 Article

Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 8, Pages 2294-2296

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03711g

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Funding

  1. Los Alamos National Laboratory Directed Research and Development (LDRD)
  2. Director's Postdoctoral Fellowship
  3. Department of Energy, Office of Basic Energy Science, Division of Material Science and Engineering

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We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.

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