Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 40, Pages 11276-11278Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14627k
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Funding
- NSF China [20802060, 21072162, 30830092, 30921005, 91029304, 81061160512]
- Fundamental Research Funds for the Central Universities [2011121020]
- 973 program [2009CB522200]
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Alteration of lysosome acidity has been implicated in many biological events ranging from apoptosis to cancer metastasis, etc. Mesoporous silica nanoparticles doped with acid activable rhodamine-lactam and fluorescein isothiocyanate (FITC) were developed for ratiometric sensing of lysosomal pH changes in live cells with flow cytometry.
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