Journal
HUMAN HEREDITY
Volume 50, Issue 1, Pages 57-65Publisher
KARGER
DOI: 10.1159/000022891
Keywords
linkage disequilibrium; isolated populations; gene mapping
Categories
Funding
- NIGMS NIH HHS [GM-52290] Funding Source: Medline
Ask authors/readers for more resources
Population isolates are increasingly being used in attempts to map genes underlying complex diseases. To further explore the utility of isolates for this purpose, we explore linkage disequilibrium patterns in polymorphisms from two regions (VWF and NF1) in three isolated populations from Finland. At the NF1 locus, the Finnish populations have greater pairwise disequilibrium than populations from Africa, Asia, or northern Europe. However, populations from 'New Finland' and 'Old Finland' do not differ in their disequilibrium levels at either the NF1 or the VWF locus. In addition, disequilibrium patterns and haplotype diversity do not differ between a sample from the Aland Islands, Finland, and a collection of outbred Centre d'Etude du Polymorphisme Humain families. These results show that linkage disequilibrium patterns sometimes differ among populations with different histories and founding dates, but some putative isolated populations may not significantly differ from larger admired populations. We discuss factors that should be considered when using isolated populations in gene-mapping studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available