4.7 Article

Direct synthesis of pyrroles via a silver-promoted three-component reaction involving unusual imidazole ring opening

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 48, Pages 12855-12857

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14716a

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Funding

  1. Ministry of Health, Singapore [NMRC/H1N1R/001/2009]

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A novel silver-promoted three-component reaction toward the synthesis of multifunctionalized pyrroles has been developed. This reaction involves an unusual imidazole ring decomposition, presumably via 1,5-isomerization and subsequent hydrolysis.

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