4.7 Article

Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 40, Pages 11264-11266

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14578a

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Funding

  1. US National Science Foundation [CHE-0910845]
  2. US National Institutes of Health [5R21CA135585]
  3. NATIONAL CANCER INSTITUTE [R21CA135585] Funding Source: NIH RePORTER

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A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.

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