Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 31, Pages 8835-8837Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10924c
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Funding
- American Heart Association (SDG) [0930140N]
- PRESTO of Japan Science and Technology Agency
- Institute of Translational Medicine and Therapeutics of the University of Pennsylvania
- National Institutes of Health [EB-011687]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL081185] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB011687] Funding Source: NIH RePORTER
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A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
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