4.7 Article

Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 23, Pages 6644-6646

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10880h

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Funding

  1. National Natural Science Foundation of China, Ministry of Science and Technology [2009ZX09501-006, 2010CB833305]
  2. Chinese Academy of Sciences
  3. Higher Education Commission of Pakistan

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A highly enantioselective Michael addition of 2-oxindoles (1) to vinyl selenone (2) in RTILs catalyzed by a Cinchona alkaloid-based thiourea has been developed in high yields (80-91%) with excellent enantioselectivities (up to 95% ee).

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