4.7 Article

Tunable stereoselective alkene synthesis by treatment of activated imines with nonstabilized phosphonium ylides

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 7, Pages 2158-2160

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04739b

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Funding

  1. National Natural Science Foundation of China [20972147, 20732006]
  2. National Basic Research Program of China (973 Program) [2010CB833300]
  3. Chinese Academy of Sciences

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A broad range of readily accessible N-sulfonyl imines undergo olefination reaction with nonstabilized phosphonium ylides under mild conditions to afford an array of both Z- and E-isomers of 1,2-disubstituted alkenes, allylic alcohols, and allylic amines in good yields and with greater than 99 : 1 stereoselectivity.

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