Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 26, Pages 7458-7460Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11490e
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Funding
- National Basic Research Program of China (973 Program) [2007CB936000]
- National Natural Science Funds for Distinguished Young Scholar [20725518]
- National Key Natural Science Foundation of China [21035003]
- Science and Technology Development Programs of Shandong Province of China [2008GG30003012]
- Key Natural Science Foundation of Shandong Province of China [ZR2010BZ001]
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We demonstrate a tumor mRNA-dependent drug carrier for controlled release of doxorubicin (Dox) and intracellular imaging based on gold nanoparticle-molecular beacon. Fluorescent Dox is released effectively and induces apoptosis in breast cancer cells but not in normal cells. Significantly, the release of Dox is correlated positively with the quantities of tumor mRNA, which is according to various stages of tumor progression, and so can decrease effectively side effects of Dox.
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