Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 36, Pages 10025-10027Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13597j
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Funding
- National Institute of General Medical Sciences [GM077596, 5 T32 GM070421]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM077596, T32GM070421] Funding Source: NIH RePORTER
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The Fe(II) and alpha-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.
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