4.7 Article

A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 29, Pages 8301-8303

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12386f

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Funding

  1. National Basic Research Program of China [010CB126100]
  2. National High Technology Research and Development Program of China [2011AA10A207]
  3. National Natural Science Foundation of China [21076077]
  4. China 111 Project [B07023]
  5. Shanghai Leading Academic Discipline Project [B507]
  6. Fundamental Research Funds for the Central Universities

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The first highly selective and sensitive fluorescent probe Z1 for detection of carbonic anhydrase IX (CA IX) over isoforms CA I and CA II was developed. As demonstrated, Z1 worked effectively in both enzymatic systems and living hypoxia cells.

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