Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 20, Pages 5708-5710Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10481k
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Funding
- NSFC [20805038, 21075104]
- MOE [200803841013]
- National Basic Research Program of China [2007CB935603, 2010CB732402]
- National Key Scientific Program of China [2011CB911000]
- China National Grand Program on Key Infectious Disease [2009ZX10004-312]
- NIH
- Procter and Gamble
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We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs.
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