Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 6, Pages 1773-1775Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04092d
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Funding
- National Research Foundation [2010-0008165]
- Gyeonggi Research Center (GRRC) program of Gyeonggi province [GRRC-HUFS-2010-A01]
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A nonfluorescent coumarin-malonitrile conjugate (1) was transformed into a strongly fluorescent molecule through the Michael addition of a thiol group to the alpha,beta-unsaturated malonitrile of 1. The molecular probe has exhibited a highly selective fluorescence response toward biothiols (Cys, Hcy, GSH) with micromolar sensitivity both in vitro and in vivo.
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