4.7 Article

Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 1, Pages 448-450

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02188a

Keywords

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Funding

  1. BBSRC [BBE025099]
  2. Altajir Trust
  3. Advantage West Midlands
  4. European Regional Development Fund (Birmingham Science City)
  5. BBSRC [BB/E025064/1, BB/E025099/1] Funding Source: UKRI
  6. Biotechnology and Biological Sciences Research Council [BB/E025064/1, BB/E025099/1] Funding Source: researchfish
  7. Medical Research Council [G0801056B] Funding Source: researchfish

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In vitro evidence for the isoform-specific partitioning of cadmium and zinc ions between the two C. elegans metallothioneins is presented. This observation is discussed in terms of isoform-specific affinities towards zinc and cadmium and the implications of our study on the in vivo roles of C. elegans metallothioneins.

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