Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 1, Pages 529-531Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02253e
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Funding
- NIH [GM008353, NS059690, AG031291]
- Abe and Irene Pollin CBD Fund
- Alzheimer's Association [IRG-09-130689]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008353] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS059690] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K99AG031291, R00AG031291] Funding Source: NIH RePORTER
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A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.
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