Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 13, Pages 3793-3795Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04733c
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Funding
- National Science Foundation [CBET-0617240]
- National Institutes of Health [U01ES016026]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [U01ES016026] Funding Source: NIH RePORTER
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Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.
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