Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 33, Pages 9483-9485Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13097h
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Funding
- CNRS
- French Research Ministry [ANR-08-BLAN-0114-01]
- LyonBioPole consortium
- French Association Vaincre la Mucoviscidose (against Cystic Fibrosis)
- Region Rhone-Alpes (Cluster de Recherche Chimie)
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Atomic force microscopy reveals that Pseudomonas aeruginosa LecA (PA-IL) and a tetra-galactosylated 1,3-alternate calix[4]arene-based glycocluster self-assemble according to an aggregative chelate binding mode to create monodimensional filaments. Lectin oligomers are identified along the filaments and defects in chelate binding generate branches and bifurcations. A molecular model with alternate 90 degrees orientation of LecA tetramers is proposed to describe the organisation of lectins and glycoclusters in the filaments.
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