Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 29, Pages 8370-8372Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10991j
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Funding
- NIH/NIGMS [R25 (EM061347)]
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Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.
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