Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 35, Pages 9846-9848Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12654g
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Funding
- Eng. Phys. Sciences Res. Council [EP/H006915/1, EP/H005625/1]
- EPSRC [EP/H006915/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H006915/1] Funding Source: researchfish
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The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.
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