Palladium-catalyzed 1,4-addition of diarylphosphines to alpha,beta-unsaturated N-acylpyrroles

Highly stereoselective asymmetric 1,4-addition of diarylphosphines to alpha,beta-unsaturated N-acylpyrroles catalyzed by a PCP pincer-Pd complex has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (91-99% ee) under mild conditions. The products obtained can be further converted into chiral phosphine-oxazoline ligands.