4.7 Article

A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 40, Pages 11330-11332

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14107d

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Funding

  1. National Natural Science Foundation of China [21021062, 21027013, 21075064, 90813020]
  2. National Basic Research Program of China [2007CB925102]

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A Zn2+ tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.

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