Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 26, Pages 7425-7427Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11925g
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- Direction Generale de l'Armement
- Sophie Lecomte and Laurent Servant
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Surface-Enhanced Raman Spectroscopy (SERS) was performed to detect label-free RNA. We defined conditions which make it possible to probe the four bases of RNA, in single strands of polyadenosine (pA), polyuridine (pU), polycytosine (pC) and polyguanosine (pG). We therefore present below a quantitative analysis of mixtures of non-hybridized single strands, based on the deconvolution of the SERS mixture spectrum into the relative contributions of the SERS spectra of each constituent.
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