Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 47, Pages 12613-12615Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15804j
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Funding
- National Science Foundation
- NIH [EB003008, GM061851]
- Pfizer
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003008] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061851] Funding Source: NIH RePORTER
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We describe a class of zwitterionic sulfobetaine (SB) lipids with fascinating salt-dependent properties. SB lipids are zwitter-neutral across a broad pH range; however they have negative surface potentials in the presence of anions and two salt-dependent transition temperatures. These new SB lipids provide insight on the role of charge orientation at the membrane interface and may be useful components in drug delivery systems.
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