4.7 Article

Fluorescent DNA chemosensors: identification of bacterial species by their volatile metabolites

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 41, Pages 11435-11437

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14871k

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Funding

  1. U.S. National Institutes of Health [GM067201]
  2. Croucher Foundation
  3. Swiss National Science Foundation
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067201] Funding Source: NIH RePORTER

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Polyfluorophores built on a DNA scaffold (ODFs) were synthesized and tested for fluorescence responses to the volatiles from M. tuberculosis, E. coli and P. putida in closed Petri dishes. Two sensors in a pattern-based response could distinguish the bacterial strains accurately, suggesting the use of ODFs in rapid identification of infectious agents.

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