4.7 Article

Efficient synthesis of polysubstituted isochromanones via a novel photochemical rearrangement

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 39, Pages 11098-11100

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14269k

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Funding

  1. China NSFC [20802013, 21002018, 21072038]
  2. HIT.NSRIF [01107866, 01107986]
  3. Wenzhou Science and Technology Program [G20100056]

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A novel and convenient approach to the synthesis of polysubstituted isochromanones is described. Irradiation of 2-formyl phenylalkeno-derivatives with UV light in benzene solution afforded the corresponding products in up to 98% yield. The possible reaction mechanism is proposed and further supported by the isotopic experiments.

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