Journal
VETERINARY JOURNAL
Volume 159, Issue 1, Pages 10-17Publisher
BAILLIERE TINDALL
DOI: 10.1053/tvjl.1999.0406
Keywords
BSE; scrapie; CJD; agent inactivation
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The unconventional agents that cause transmissible degenerative encephalopathies, such as bovine spongiform encephalopathy, scrapie, and Creutzfeldt-Jakob disease (CJD), are relatively resistant to inactivation by standard decontamination procedures. The only methods that appear to be completely effective under worst-case conditions are strong sodium hypochlorite solutions or hot solutions of sodium hydroxide. Other procedures that result in significant degrees of inactivation are described. The infectivity levels in histologically-fixed tissue can be reduced substantially by treatment with concentrated formic acid without adversely affecting the microscopic quality of the tissue. (C) 2000 Harcourt Publishers Ltd.
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