Journal
PHARMACEUTICAL BIOLOGY
Volume 38, Issue 5, Pages 367-370Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1076/phbi.38.5.367.5970
Keywords
Chromolaena odorata (Linn.) King and Robinson; antidiarrhoeal; anti-inflammatory; antipyretic; antispasmodic
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A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p < 0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and antispasmodic properties of C. odorata.
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