4.7 Article

Morpholine catalyzed direct C3 alkenylation of indoles with alpha,beta-unsaturated aldehydes

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 28, Pages 8097-8099

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12220g

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Funding

  1. Peking University
  2. National Science Foundation of China [20872003]
  3. National Basic Research Program of China (973 Program) [2009CB825300]

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Organocatalytic direct C3 alkenylation of indoles has been developed. Simple and readily available morpholine trifluoroacetic acid salt is employed as an efficient catalyst in this oxidative dehydrogenative reaction. Simplicity and practicality constitute the most attractive advantages of this reaction.

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